Ferric Carboxymaltose Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus. Pharmacodynamic properties. Ferric carboxymaltose (FCM) solution for injection/infusion contains iron in a stable ferric state as a complex with. Find a comprehensive guide to possible side effects including common and rare side effects when taking Injectafer (Ferric carboxymaltose Injection) for.
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FERRIC CARBOXYMALTOSE PDF
In all trials, ferric carboxymaltose was administered until each patient had received his or ferric carboxymaltose calculated total iron replacement dose. Haemoglobin-related outcomes improved in patients with iron-deficiency anaemia receiving ferric carboxymaltose.
Ferinject (ferric carboxymaltose) - Summary of Product Characteristics (SmPC) - (eMC)
Treatment with ferric carboxymaltose was associated with rapid and sustained increases from baseline in haemoglobin levels. Ferric carboxymaltose was considered to be as least as effective ferric carboxymaltose ferrous sulfate with regard to changes from baseline in haemoglobin levels or the proportion of patients achieving a haematopoietic response ferric carboxymaltose various timepoints.
In general, improvements in haemoglobin levels ferric carboxymaltose more rapid with ferric carboxymaltose than with ferrous sulfate. Ferritin monitoring after replacement therapy There is limited data from study VIT-IV-CL which demonstrates that ferritin levels decrease rapidly weeks following replacement and more slowly thereafter.
The mean ferritin levels did not drop to levels where retreatment might be considered during the 12 weeks of study follow up.
Thus, the available data does not clearly indicate an optimal time for ferritin retesting although assessing ferritin levels earlier ferric carboxymaltose 4 weeks after replacement therapy appears premature.
Thus, it is recommended that further re-assessment of ferritin should be made by the clinician ferric carboxymaltose on the individual patient's condition.
The volume of the central compartment corresponds well to the volume of the plasma approximately 3 litres. The iron injected or infused was rapidly cleared from the plasma, the ferric carboxymaltose half-life ranged from 7 to 12 hours, the mean residence time MRT from ferric carboxymaltose to 18 hours.
Renal elimination of iron was negligible.
Ferric Carboxymaltose Injection
Preclinical studies indicate that iron released from Ferinject does cross the placental barrier and is excreted in milk in limited, controlled amounts. In reproductive ferric carboxymaltose studies using iron replete rabbits Ferinject was associated with minor skeletal abnormalities in the fetus.
In a fertility study in rats, there were no effects ferric carboxymaltose fertility for either male or female animals. No long-term studies in animals have been performed to evaluate the carcinogenic potential of Ferinject.
No evidence of allergic or immunotoxic potential has been observed. Ferric carboxymaltose controlled in-vivo test demonstrated no cross-reactivity of Ferinject with anti-dextran antibodies. How should this medicine be used?
Ferric carboxymaltose injection comes as a solution liquid to inject ferric carboxymaltose into a vein by a doctor or nurse in a medical office or hospital outpatient clinic.
Ferric carboxymaltose: a review of its use in iron-deficiency anaemia.
It is usually given as a total of 2 doses, spaced at least ferric carboxymaltose days apart. If your iron levels become ferric carboxymaltose after you finish your treatment, your doctor may prescribe this medication again.
Ferric carboxymaltose injection may cause severe or life-threatening reactions during and shortly after you receive the medication. Your doctor will watch you carefully while you receive each dose of ferric carboxymaltose injection and for at least 30 minutes afterwards.
- Ferric Carboxymaltose Injection: MedlinePlus Drug Information
- Ferinject (ferric carboxymaltose)
- Why is this medication prescribed?
ferric carboxymaltose Your doctor will also check your blood pressure frequently during this time. Intravenous iron therapy in patients with iron deficiency anemia: Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: Large-dose intravenous ferric carboxymaltose ferric carboxymaltose for iron deficiency anemia in heavy uterine bleeding: Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: