Fagonia indica Burm. f., Fl. Ind. tab. fig. 1. Hadidi in Candollea 21 (1): ; in Rech. f., Fl. Iran. tab. 5. ; in Tackholm, Stud. Fl. Egypt. Pak J Pharm Sci. Jan;27(1) A new natural gel of Fagonia indica Burm f. extract for the treatment of burn on rats. Rasool BK(1), Shehab NG(2), Khan. Abstract. Fagonia indica is a traditionally used phytomedicine to cure hepatic ailments. However, efficient validation of its hepatoprotective.


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During this time interval, number of animal deaths was expressed in percentile. Liver Injury Mouse Model TAA is a hepatotoxicant widely used in acute fagonia indica chronic liver injury studies [ 49 ] and to understand fibrogenic mechanisms [ 5051 ].

Fagonia indica Burm.f. — The Plant List

Fagonia indica Design Normal saline 0. The dosage plan is illustrated in Table 1. Animals were grouped in cages three days before starting the experiment. By the end of the study period, blood was collected and animals were sacrificed for liver tissue samples of all study groups.

Pictures of intact liver organs were also taken for macroscopic analysis of liver morphology. Animal fagonia indica and treatment plan.

Liver Function Tests Blood samples were collected using a cardiac puncture method. A sterile 3 mL syringe was used for blood collection from each mouse individually, and isolated blood was immediately transferred to nonheparinized tubes.

Pictures of gels were taken for densitometric analyses of PCR bands. Primers used in this fagonia indica. Results were expressed as error of mean SEM of obtained values. All statistical analyses were performed using GraphPad Prism version 5.

Acute Toxicity The acute toxicity test was crucial for the determination of plant extract test dose and safety. This value was considered the maximum nonlethal dose MNLD as described elsewhere [ 53 ].

Fagonia indica Improves Liver Function Tests Serum biochemical analysis is an important indicator of liver function. Significant increased levels of serum ALTASTtotal proteins fagonia indica, and globulin were observed in the TAA group compared to the control depicting a successful establishment of a hepatic injury mouse model.

Of note, these levels were much similar to PE and control groups Figure 1. fagonia indica

A new natural gel of Fagonia indica Burm f. extract for the treatment of burn on rats.

Serum biochemistry of liver injury mouse model treated with Fagonia indica. The TAA group showed massive destruction of hepatocyte structures, increased necrosis, macrophage infiltration in the perivenular zone, tissue degeneration, and mononuclear cells in fagonia indica collections.

Histopathological changes of mouse liver tissues showing recovery of injury after treatment fagonia indica Fagonia indica. Liver organs and hepatic tissue sections of the study groups were analyzed for gross morphology and histopathological alterations, respectively.

Fagonia - Wikipedia

Histology shows repair of hepatic structure towards normal architecture due to exposure with fagonia indica extract showing injury fagonia indica activity of Fagonia indica.

TUNEL assay staining of mouse liver tissues showing recovery of injury after treatment with Fagonia indica. Images shown are representative of at least three replicates.

Gene expression analysis of proinflammatory cytokines and hepatic markers with or without injury after treatment with Fagonia indica.

A new natural gel of Fagonia indica Burm f. extract for the treatment of burn on rats.

fagonia indica C1 gel electrophoresis of conventional PCR products performed for albumin and krt Graphs presented show fagonia indica change in gene expression of candidate genes asand. In conclusion, these results provide a molecular basis of reversal of hepatic injury on treatment with Fagonia indica extract Figure 4 c.


Expression of these genes was significantly upregulated in Fagonia indica compared to the control group, andresp. Expression of MyD was reduced by about Effect of Fagonia indica on expression regulation of immune regulatory genes: Discussion Fagonia indica plants with lesser side effects and more compatibility to body physiology render phytomedicine a comparatively safe treatment option since ancient times [ 54 ].

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