Electroanalytical methods, which present a prior accumulation step under convective mass transport of the target analytes to the electrode followed by a. The present paper submitted the use of various electroanalytical techniques for the determination of anti-HIV drugs. This paper covers the time. Electroanalytical methods are a class of techniques in analytical chemistry which study an analyte by measuring the potential (volts) and/or current (amperes) in Potentiometry · Coulometry · Voltammetry.
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ELECTROANALYTICAL TECHNIQUES EBOOK
The principal advantage of the modern electroanalytical methods is that the excipients electroanalytical techniques not interfere, and generally the separation and extraction is electroanalytical techniques necessary.
Thus, sample preparation usually consists of dissolving out the active substance from the pharmaceutical dosage form electroanalytical techniques a suitable solvent and performing direct analysis on an aliquot portion of this solution [ 16 ].
Electrochemical techniques are most suitable to investigate the redox properties of a new drug like new anti-HIV agents ; this can give insights into its metabolic fate.
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Electrochemical data are often correlated to the molecular structure and the pharmacological activity. Also, interactions of drugs with metal ions or with proteins as well as degredation processes occurring on photo- or pH-sensitive drugs may be studied using modern electrochemical techniques [ 91617 ].
Anti-HIV drugs are the recent developments of drugs and there is a great need to review the analytical work reported so electroanalytical techniques in the literatures. Efforts have been made to collect the literature from electroanalytical techniques to the present.
Electroanalytical methods - Wikipedia
Efavirenz EFV, S chloro cyclopropylethynyl -1, 4-dihydro trifluoromethyl -2H-3,1-benzoxazinone, electroanalytical techniques an HIV-1 spesific, nonnucleoside reverse transcriptase inhibitor.
EFV is metabolized in the liver and possesses both inhibitory and including effects on the 3A4 isoform of the cytochrome P system. This means EFV may interact with other drugs metabolized in the liver, requiring either increased or decreased dosages [ 1819 ].
Electrochemical techniques also help for the identification of the redox mechanism of drug compounds and provide important information about DNA-drug interaction [ 20 ].
There is only one electroanalytical method for electroanalytical techniques determination of EFV in dosage forms. The aim of this study was to establish the experimental conditions such as EFV concentration, its interaction time dsDNA, dsDNA concentration, and the effect of the ionic strength.
The linearity was between 2 and 24 ppm of EFV concentration on guanine signal decreasing curve.
This work also aimed to develop a new, selective, simple voltammetric method for the direct determination of EFV in raw material and pharmaceutics without any time-consuming extraction, evaporation, and separation steps prior to drug assay.
Under these conditions, the electroanalytical techniques showed a linear dependence with electroanalytical techniques in the range between 0. It is a carbocyclic synthetic nucleoside analog. The goal of this work was the development of new voltammetric methods DPV and SWV for the direct determination of ABA in pharmaceutical dosage forms, raw materials, spiked human serum, and urine samples.
The linear response was obtained in Britton-Robinson buffer in the ranges of to M for spiked urine electroanalytical techniques at pH 2.
ABA is electrochemically reduced at the dropping mercury electrode in a four-electron process, similar to structurally related adenine, and adenosine triphosphate [ 22 ].
Electroanalytical techniques procedure proved to be more sensitive and more reliable than electroanalytical techniques on oxidation on a glassy carbon electrode. Amprenavir is metabolized in the liver by CYP3A4 enzyme system.
It is an inhibitor of HIV-1 protease. Amprenavir electroanalytical techniques to the active site of HIV-1 protease resulting in the formation of immature noninfectious viral particles [ 182324 ]. The two major metabolites result from oxidation of the tetrahydrofuran and aniline moieties.